When Shoutarou Tatewaki crosses paths with Sakurako Kujou, his world takes a riveting turn. Initially suspicious of her involvement in a local disappearance, he soon discovers her remarkable skill in examining bone specimens. Despite Sakurako's penchant for animal bones, her fascination with human remains sparks controversy. As Shoutarou joins the peculiar osteologist on her investigations, which often involve decaying bodies, they find themselves entangled in a web of unresolved mysteries. Amidst these grim encounters, a deeper enigma looms over their partnership. 'Sakurako-san no Ashimoto ni wa Shitai ga Umatteiru' delves into the bond between these unlikely companions, showcasing how bones reveal the end while only people can unveil the intricate stories of life.