Embarking on a new chapter at St. Miator’s Girls Academy, Nagisa Aoi, a transfer student, stumbles upon a captivating student on her first day, leading to an unexpected visit to the infirmary. Meeting her lively roommate Tamao Suzumi, Nagisa delves into the school's intricate social dynamics and learns about the prestigious title of Etoile, held by none other than the enchanting Shizuma Hanazono. As Nagisa's connection with Shizuma blossoms, it sparks gossip across the campus, yet Nagisa can't shake a feeling of unease. Strawberry Panic! unravels the intertwined lives of Nagisa, Shizuma, and their companions at the three renowned schools, navigating relationships, suppressed emotions, and fresh opportunities.