Expelled from Heaven due to their rebellious nature, the Anarchy Sisters, Panty and Stocking, team up with the priest Garterbelt in Daten City to earn their way back by vanquishing ghosts. Armed with unconventional weapons crafted from their lingerie, these angels embark on their mission. However, their lackadaisical approach to ghost-hunting, with Panty indulging in promiscuity and Stocking in sweet treats, constantly derails their efforts. Join the chaotic duo as they combat supernatural forces, grapple with bodily fluid mishaps, and struggle to stay focused in the zany world of Panty & Stocking with Garterbelt.