Seto, a mundane high school student, finds himself constantly pestered by his troublemaking classmate Anjou. Despite their contrasting personalities – Seto's seriousness and Anjou's liveliness – the dynamic duo forms an unexpected bond. Anjou's teasing brings joy to her, though Seto struggles to cope with her antics, unaware that his reactions fuel her amusement. The line blurs between playful banter and genuine affection as Anjou's true feelings remain a mystery. Yancha Gal no Anjou-san captures the daily escapades of these opposites, showcasing how lighthearted teasing can blossom into a meaningful connection.