In his third year of college, Shinichi Sakurai yearns for peaceful days but finds himself entangled with his energetic and well-endowed junior, Hana Uzaki. Determined to prevent Sakurai from repeating his lonely high school days, Uzaki fills his life with adventures, dragging him along for fun. Despite finding her teasing exasperating, Sakurai discovers the joy of companionship through their shared escapades, often leading to comical misunderstandings. 'Uzaki-chan Wants to Hang Out!' is a slice-of-life tale chronicling the hilarious escapades of the contrasting duo as they forge an unconventional yet endearing bond.