In a world gripped by fear of shape-shifting monsters called Yoma, humanity relies on the Claymore Organization, employing female warriors with Yoma blood to eradicate the threat. Among them is Clare, a determined low-ranking member seeking vengeance and struggling to balance her humanity. As she embarks on perilous missions, she unveils the dark secrets of the organization and finds solace in the bonds of sisterhood amidst a grim reality.