During a school trip to Taiwan, Shio Ogura, an ordinary Japanese high schooler, is unexpectedly ambushed by otherworldly creatures. In this chaotic encounter, the government's special unit, DOGOO, intervenes with their E-Gene Holders—individuals armed with weapons embodying historical luminaries' spirits. Surprisingly, Shio emerges as one of these E-Gene Holders, manifesting the spirit of Oda Nobunaga while attempting to save a comrade.

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