Rumors swirl in a food container factory about Mako Higari's supposed promiscuity, catching the attention of her coworker, Kinoshita. Intrigued, Kinoshita decides to test the waters and ends up in a hotel room with Mako. As they prepare for intimacy, a bizarre phenomenon interrupts their moment—a sudden nosebleed from Mako whenever she touches impurities. Shocked and unsettled, Kinoshita flees, leaving Mako to grapple with her unique condition. Follow Mako's journey in Botabota as she strives for a normal life amidst a world seemingly tainted by filth at every turn.