When second-year high school student Sora Akizuki confesses his feelings to underclassman Miya Fuwa, he faces rejection as she harbors affections for another. The object of her affection, Asahi Suzukaze, leads the enigmatic 'Clinical Trial Club,' drawing Sora into its fold. However, Sora soon learns of Asahi's own unrequited love, directed towards a boy known as the 'prince of clinical trials' for aiding her during a critical time. To his surprise, this mysterious savior turns out to be none other than Sora himself, a mischievous figure from their shared past. Thus commences a high-energy romantic comedy within the realms of clinical trials, entangling a web of intricate love connections.