Lupin III, a renowned thief with a lineage of daring bandits, embarks on high-stakes heists in the U.S. for the first time. Preferring to steal from the shady elite, Lupin teams up with a cast of intriguing accomplices: the stoic ex-mafia gunman Jigen, the enigmatic samurai-esque swordsman Goemon, and the alluring thief Fujiko, who shares a tumultuous romance with Lupin amidst their competitive endeavors. Pursuing Lupin tirelessly is Interpol, led by the relentless Inspector Zenigata. Their complex relationship oscillates between respect and enmity, occasionally forcing them into reluctant alliances before reverting to their adversarial dynamic once the danger has passed.