High school teacher Nozomu Itoshiki, plagued by a desire to end his life, grapples with the monotony of existence. Despite his relentless despair, he is constantly entangled in the peculiar and often suspicious dilemmas of his eccentric students. As he navigates absurd predicaments to protect his pupils from despair, Itoshiki seeks solace in the whimsical chaos of his daily escapades, all while yearning for the elusive peace of death.