Yosuke Kobayashi, a police detective, undergoes a life-altering experience when a serial killer identifies something unique about him. This killer commits a heinous act against Kobayashi's wife, triggering a battle of multiple personalities within Kobayashi. As he delves into a labyrinth of deviants and dark entities, he is immersed in a web of intricate connections. MPD-Psycho captivates audiences with its riveting narrative and the striking, polished art style by Tajima, marking it as the manga sensation of the era.