Once revered as the Shogunate's top executioner, Ittou Ogami's life crumbles when the deceitful Yagyuu Clan frames him for treason and slaughters his family, leaving only his son Daigorou untouched. Branded with shame and loss, Ittou transforms into a hired killer, embarking on a vengeful journey with his son by his side. Known as the deadly duo 'Lone Wolf and Cub,' they traverse the land, accumulating a reputation for their precise and ruthless executions, all while fixated on annihilating the treacherous Yagyuu Clan.