In the midst of a tumultuous family life, 14-year-old Asumi Kamogawa nurtures a deep fascination with the stars, mentored by the wise ghost Lion-san. Determined to pursue her cosmic dreams, she joins the Tokyo Space School, where she befriends a diverse group: the bluntly honest Shinnosuke Fuchuuya, the inspired Kei Oumi, the mysterious Marika Ukita, and the laid-back yet sharp Shuu Suzuki. Against the backdrop of an alternate future marked by Japan's failed space endeavor in 2010, Futatsu no Spica follows these high schoolers on their journey of self-discovery and ambition towards the vast expanse of the universe.