In a world akin to Earth but infused with magic, young women exhibit magical abilities that fade with age. A pivotal invention, the magic engine, amplifies these powers, revolutionizing industry and transport. However, the emergence of the Neuroi, mysterious entities spreading destruction, threatens humanity. As the Neuroi advance, witches armed with magic engines and Striker Units, dubbed 'Strike Witches,' rise to defend against the invasion. Amidst a crucial Neuroi threat in 1939, Anabuki Tomoko, a renowned Imperial Army Witch, finds herself unexpectedly stationed in Suomus alongside a group of underestimated witches. Together, they form the 'Misfits Squadron,' striving to combat the Neuroi incursion and prove their worth.