Mardock City, known for its harshness, has never been kind to Rune Balot, a young homeless prostitute. Her life takes a unexpected turn when Shell Septinos, a casino manager, offers her shelter. However, this apparent refuge shatters when Shell betrays her, pushing Balot to the brink of death. Saved by Dr. Easter, she undergoes a life-altering operation granting her extraordinary abilities like heightened senses and control over electronics. Sacrificing her voice, Balot gains immense power. With her newfound skills, alongside Dr. Easter and a unique mouse companion named Œufcoque Penteano, Balot embarks on a quest for vengeance against her would-be killer.