In the futuristic Heartland city, Yuuma Tsukumo, an aspiring Duel Monsters champion, embarks on a quest after meeting Astral, a mysterious spirit lacking memories scattered across 99 dangerous cards known as Numbers. With his father's dueling teachings and Astral's guidance, Yuuma faces intense duels against sinister foes seeking the Numbers for nefarious purposes, delving into the depths of human desires and confronting his own limits in the pursuit of victory and self-improvement.