Immersed in the comfort of his two-dimensional world, Hikari Tsutsui finds solace in video games and anime, facing ridicule and isolation from his peers. His only companion, Yuuto Itou, shares his passion for gaming and stands by him. During a pool cleaning duty, Tsutsui encounters Iroha Igarashi, a notorious figure he initially avoids due to her reputation. Despite her blunt nature and unfavorable gossip, Tsutsui is wary of entangling himself with her. As their paths intertwine, 3D Kanojo: Real Girl delves into the lives of these social misfits—Tsutsui navigating unfamiliar emotions and Igarashi determined to shatter his emotional barriers.