Running the Layton Detective Agency, Katrielle Layton, daughter of the famed archaeologist Professor Hershel Layton, tackles eccentric cases with her assistant Noah Montoir and talking canine Sherl. From investigating a cursed house and a demon-infused dress to dealing with a client's zombie spouse, the agency handles a range of peculiar mysteries. Amidst these oddities, Katrielle diligently pursues the truth behind her father's disappearance, making each new case a stepping stone towards solving the ultimate enigma of her life.