After a narrow escape from a deadly trap, Ning Yuan, alongside the intimidating gangster He Zhiyang and the frantic doctor Su Jin, awakens to a grim reality. Stranded on a remote island plagued by deadly viruses, grotesque mutations, and aggressive tribes, they must confront the harsh truth of their predicament. As they grapple with their dire circumstances, another group on the island faces a similar plight. Bound by a common struggle for survival, these disparate individuals must unite, setting aside their individual agendas to overcome the challenges and adversaries that stand in the way of their freedom.