In a world where Puberty Syndrome is dismissed as a mere myth, high schooler Sakuta Azusagawa stands as a witness to its reality. Encountering the enigmatic Mai Sakurajima, a former child star shrouded in mystery, he learns of her struggle with this supernatural affliction. As Sakuta delves deeper into the secrets of Puberty Syndrome, he finds himself drawn into a web of connections with other girls grappling with their own inexplicable issues.