After the Altana Liberation Army retreats temporarily from the Kabuki District, the war's dynamics appear to shift positively. Yet, amidst the ongoing clashes between the Oniwaban, Shinsengumi, district dwellers, and the army's remnants, Edo faces a new crisis with the abduction of Gengai Hiraga, the city's esteemed inventor. Gengai, instrumental in neutralizing the enemy's armaments, now faces the threat of losing control over his nanomachine virus. Simultaneously, a planet-destroying laser activates on the Liberation Army's mothership in Earth's orbit, setting the stage for a high-stakes confrontation. With Shinsuke Takasugi and the Kiheitai joining the fray to prevent the catastrophic weapon's deployment, the Yorozuya and their comrades find themselves in a precarious position, battling on two fronts to safeguard Edo and the entire world.