Kill Me Baby follows the comedic escapades of Yasuna, an ordinary high school girl, and Sonya, her best friend who also leads a double life as an assassin. Sonya's deadly skills frequently backfire in their day-to-day school routine, resulting in mishaps like Yasuna's frequently injured wrist. Despite Yasuna's ninja training, she remains unprepared for the unpredictable and uproarious misadventures that unfold in this action-packed 4-panel manga series.