After witnessing the destruction of her temple and the massacre of its inhabitants by malevolent ninjas, Isanami, a young priestess from Izumo, escapes into the forest. Serendipitously, she encounters Saizou Kirigakure, a ronin ninja from the Iga clan. Together, they journey to Ueda Castle seeking aid from Yukimura Sanada. As Isanami's extraordinary and dangerous powers come to light, Sanada assembles a formidable group of ten warriors to support her cause. Thus commences the tale of Brave 10, unfolding in the chaos of the Warring States era. Saizou and Isanami traverse war-torn lands, recruiting skilled fighters under Yukimura's banner. Their quest leads them on a perilous path, evading those who covet Isanami's ominous abilities for their own sinister purposes.