Decades after the adventures of Keita Amano and his Youkai companions, a new crisis emerges in a city plagued by the malevolent Onimaro virus. This epidemic transforms individuals into Kaodeka Oni, unleashing chaos and destruction. As the once-legendary Youkai-controlling wristwatch fades into obscurity, a new generation must rise. Chosen wielders of the new Youkai Watch are humanity's last hope against the impending doom, tasked with saving both worlds from annihilation.