In a dire future where Earth faces annihilation from alien attacks, the Earth Defense Force forms to counter the ruthless Gamilas threat. When a beacon of hope emerges from the distant planet Iscandar, offering a chance at salvation through advanced technology, the iconic Space Battleship Yamato is chosen to embark on a perilous journey spanning light-years. Led by Captain Juuzou Okita, the crew, including young officers Susumu Kodai and Daisuke Shima, must adapt quickly to the ship's cutting-edge systems and combat the relentless Gamilas forces. As they navigate through treacherous space, the inexperienced but determined team of Uchuu Senkan Yamato 2199 faces unimaginable challenges, striving to secure Earth's future by reaching Iscandar and obtaining the key to humanity's survival.