In 2006, suspicious activity in accessing confidential Presidential documents prompts a scrutiny at the White House. Federal agent Leon S. Kennedy, part of the investigating team, faces a sudden blackout, unleashing a swarm of enigmatic zombies that he must combat alongside SWAT members. Concurrently, Claire Redfield from TerraSave stumbles upon a cryptic drawing during her refugee aid work, hinting at a viral outbreak victim. With a haunting curiosity, Claire delves into her own inquiry. The following day, Claire coincidentally meets Leon at the White House while advocating for a welfare facility, sharing the eerie sketch with him. Although Leon senses a connection between the White House incident and the drawing, he dismisses any correlation, departing abruptly. As distant zombie crises unfold worldwide, the repercussions escalate, profoundly impacting the nation.