Lupin, Goemon, and Jigen embark on a daring mission to the enigmatic 'Drifting Island' in search of a legendary treasure. As they navigate the island, they stumble upon the formidable 'Nanomachine' security system, setting off a dangerous chain of events. Unraveling the island's secrets leads them to Zufu, a once-prosperous nation now under the iron rule of the knife-wielding General Headhunter. Meanwhile, Fujiko delves into General Headhunter's secrets through cyber espionage. Zenigata receives a message from Lupin revealing his quest for the valuable prize. With the unexpected aid of Oleander, a mysterious officer with her own agenda, the team returns to the 'Drifting Island,' only to find themselves pursued by General Headhunter.