After being ousted from the Lupin investigation, Inspector Zenigata finds solace in a drink with Lupin and Jigen. To assist Zenigata with his latest case involving arms dealers called Shot Shell, Lupin proposes a partnership between his gang and the inspector. With Jigen, Goemon, and Fujiko by his side, Lupin collaborates with Zenigata in hijacking a Russian submarine. Their mission intensifies as they recruit scientist Karen Korinsky to navigate the sub and shield her from Shot Shell's threats. Simultaneously, the ICPO assigns a ruthless operative, Keith Hayden, to pursue Lupin and his crew. Unlike Zenigata, Keith is determined to eliminate Lupin and his associates, relentlessly tailing them with deadly intent.