In the bustling metropolis of Tokyo, Ryo Saeba, known as the City Hunter, operates as a skilled private investigator. Teamed up with his partner Kaori Makimura, Ryo receives a commission from the famous actress Emi Makaze to locate her missing brother. Little do they know that her sibling is none other than 'The Professor', a troubled former soldier set on annihilating Tokyo's Shinjuku district. As Kaori is tasked with protecting Emi, both women become entangled in The Professor's dangerous plot. Now, the City Hunter must rescue them and prevent the catastrophic destruction of downtown Tokyo.