In Venus Versus Virus, Sumire, an ordinary schoolgirl with the gift of seeing ghosts since childhood, is met with skepticism when she shares this with her loved ones. Her life takes a dramatic turn when she crosses paths with Lucia, a gothloli warrior who battles monstrous entities known as 'viruses.' Now faced with a life-altering choice, Sumire must decide whether to embrace her unique ability and join the fight against these malevolent creatures preying on humanity.