Shinichi Chiaki, a gifted musician aiming for European success, is hindered by his fear of flying. At a prestigious music university in Japan, he encounters Noda Megumi, also known as Nodame, a seemingly directionless yet talented pianist. Despite her unpolished exterior, Nodame's music captivates Chiaki. Their lives intertwine as Nodame moves in next door and harbors feelings for him. Nodame Cantabile follows their journey as they navigate their differences and aspirations in the competitive realm of music.