In the year 1580, Nobunaga Oda is on the brink of dominating Japan using a formidable army armed with advanced weapons. Among his enforcers is Ginnai Doma, a former samurai transformed into an unstoppable assassin. As Ginnai relentlessly eliminates ninjas and dissenters challenging Nobunaga's authority, Shishimaru of the Iga Ninja defies the Koga Ninja's strategies, embarking on a personal mission of vengeance to avenge his fallen comrades and take down the immortal warrior.