After a baseball defeat, the Little Busters opt for a pancake celebration. With Kyousuke Natsume's return marking a semester, Riki Naoe aids the group, old and new, in battling their internal dilemmas. As odd occurrences take place, Rin Natsume and Riki edge closer to uncovering the 'secret of this world.' Unbeknownst to them, this revelation will shatter the peaceful routine the Little Busters have built. Little Busters!: Refrain wraps up the vibrant tales of its diverse characters, laden with emotions and fortified by friendship, as they reconcile with their past regrets and vulnerabilities.