Following her father's murder, Ryuuko Matoi roams in pursuit of his killer, guided by a sole clue—the missing half of the Scissor Blade, his invention. Her quest leads her to Honnouji Academy, a prestigious school dominated by the formidable Satsuki Kiryuuin and her Elite Four subordinates. Satsuki controls the school through a hierarchy enforced by granting powerful abilities with 'Goku Uniforms' to select students. After a crushing defeat, Ryuuko encounters Senketsu, a rare and sentient 'Kamui' garment that bonds with her, enhancing her strength. Empowered by Senketsu and wielding the Scissor Blade, Ryuuko challenges the Elite Four to confront Satsuki and unravel the truth behind her father's demise.