Dr. Kenzou Tenma, a highly skilled neurosurgeon with a promising future, faces a pivotal moment when he defies orders to save a famous patient, causing a tragic outcome. Tormented by guilt, he later chooses to save a young boy over a powerful figure, leading to a downward spiral in his career. Despite facing repercussions, Tenma eventually finds himself at the helm of the hospital after a series of mysterious deaths. Years later, his past catches up with him when a former patient, now a criminal, resurfaces, compelling Tenma to confront the consequences of his actions and embark on a journey of redemption.