In the midst of a fierce battle between the corporate giant Daedalus Group and a band of rebels called the Ghost of Icarus, Black Jack crosses paths with Dr. Kiriko, a notorious figure known as Death Incarnate. Unlike Black Jack, who demands hefty payments to save lives, Dr. Kiriko offers a merciful end to his patients for a price. As the Ghost of Icarus seeks their collaboration, Black Jack is thrust into a web of morality, betrayal, and the delicate balance between life and death. With the looming threat of a catastrophic biological warfare, Black Jack races against time to heal his patients and prevent the impending doom that could spell the end of humanity.