In a Japanese prison, Joutarou Kuujou believes he's possessed by an evil spirit, refusing release to protect others. With the help of his grandfather Joseph Joestar, he discovers this 'spirit' is a powerful entity known as a 'Stand.' After a clash with a Stand user, Joutarou learns to wield his own Stand's might. But when his mother, Holy, falls prey to a deadly Stand, Joutarou embarks on a perilous journey to Egypt with his allies. Facing fierce foes and the looming threat of an immortal vampire, they must defeat evil or witness humanity's downfall.