In a world where the enigmatic Mushi are both feared and misunderstood, a wandering Mushishi named Ginko sets out to aid in the delicate balance between humans and these ethereal beings. Along his journey, Ginko encounters individuals touched by the Mushi's influence, facing the ethical dilemma of meddling in the intricate ties that bind humanity and the unseen world. As he delves deeper into the mysteries of these creatures, Ginko grapples with his role as a Mushishi and the implications of his interventions on the intricate web connecting mankind and the enigmatic Mushi.