In a whimsical twist of fate, Yachiyo Inugami, an outgoing cat enthusiast, and Suzu Nekoyama, a shy dog lover, find themselves entwined in an unexpected bond. Despite their contrasting personalities, they are inexplicably drawn together. As they unravel each other's quirks, Inugami's determined efforts to win over Nekoyama spark hilarious reactions. Their growing closeness leads them to team up with the timid Mikine Nezu and the laid-back Ushikawa Ukiji in the 'biology' club. Amid their mischievous escapades, a playful dynamic unfolds, resembling a cat-and-mouse game. Full of energy and humor, Inugami-san to Nekoyama-san follows the unconventional relationship of these high school girls with charm and wit.