In a world where mysterious Mushi beings disrupt human lives, the Mushishi traveler Ginko dedicates himself to resolving the strange and unsettling effects they cause. From time loops to telepathy, these primordial creatures bring both overt and subtle changes that intrigue Ginko as he wanders from village to village. Acting as a mediator, Ginko decides which Mushi are blessings and which are curses, navigating the blurred boundaries between the two. Some individuals embrace their newfound abilities, while others struggle to rid themselves of protective afflictions. Those entangled with Mushi must confront unforeseen consequences and confront hidden wounds to avoid unimaginable fates.