In the city of Ergastalum, Nicholas Brown and Worick Arcangelo, known as the 'Handymen,' are hired guns handling tasks others dare not touch. Engaged by both crime lords and law enforcement, they navigate a dangerous world where no job is too grim. When tasked with eliminating a local pimp, they extend their protection to Alex Benedetto, a targeted prostitute, drawing her into their fold for sanctuary. Amidst the evolving turmoil of this gritty urban landscape, once a haven for genetically-enhanced 'Twilights,' a sinister faction threatens their existence. These superhumans, born from a mysterious substance, now face ruthless persecution, plunging Ergastalum into a volatile conflict that the Handymen can no longer sidestep.