Galko, Otako, and Ojou may not seem like they'd click, being high school girls with contrasting personalities. Galko, the partygoer, is actually kind-hearted; Otako, the manga enthusiast, is blunt and plain; and Ojou, the elegant one, can be a bit absent-minded. Despite their disparities, they're inseparable best friends who enjoy discussing myths and candidly exploring female-related topics. 'Oshiete! Galko-chan' humorously showcases these three unique girls as they fearlessly tackle everyday conversations, even if Galko occasionally blushes at their daring discussions.