Following their escape from Hope's Peak Academy, Makoto Naegi and his companions align with the Future Foundation in their fight against despair. However, Naegi's loyalty is questioned when he defends a group of Remnants of Despair, leading to his arrest and trial within the organization. Alongside Kyouko Kirigiri and Aoi Asahina, Naegi faces an uncertain future as Monokuma, the ominous mechanical bear, reintroduces a deadly killing game by breaching the Foundation's security. As the cycle of despair reignites with the first casualty, Naegi, known as the Super High School-Level Lucky Student, must untangle the mystery amidst the dwindling group of survivors. In this brutal challenge, there are no more class trials—only one murderer among 16 participants, where every death signals the cease of this harrowing game.