Embarking on a cruise towards the picturesque Cenancle Island, the energetic cyborg Nene Nanakorobi, fueled by her dream of global harmony, befriends the inventive Uzal Delilah and her feline combat android, Clarion. When a devastating terrorist assault threatens their bond soon after, Uzal sacrifices herself to empower Nene with the Pandora Device housed within Clarion. This enhancement grants Nene unprecedented abilities crucial in their shared mission for peace. Together, they tackle diverse challenges—from rescuing youngsters trapped in infernos to battling rogue thieves—all while combating the mischievous and potent B.U.E.R, a quirky teddy bear-shaped laser entity. Complicating matters, Nene's guardian and brilliant inventor, Takumi Korobase, holds a peculiar fascination for B.U.E.R. As they navigate the perils of saving the world and safeguarding B.U.E.R from malevolent forces, the weight of their monumental task strains their friendship. Will their noble aspirations for world peace withstand the trials that threaten to tear them apart?