In the year A.D. 2010, a mysterious environmental shift and a deadly substance wipe out all men, leaving only women behind in a world reclaimed by nature. Amidst this dwindling population, some resign to their fate while others strive for survival through scientific means. Tokyo stands as a last bastion of civilization, a battleground where opposing factions clash over the elusive 'ICE' specimen that holds the key to humanity's salvation.