In a quaint rural village, Touta Konoe's ordinary existence takes a fantastical turn when his mentor, Yukihime, discloses her vampire nature and grants him immortality after a near-death encounter. Eager to explore beyond his confines, Touta seizes the opportunity to scale Amanomihashira, a towering structure reaching into the cosmos. His journey intertwines with the discovery of 'UQ Holders,' a covert society of fellow immortals. With newfound allies and guidance, Touta dives headfirst into a one-of-a-kind, enchanting odyssey.