From a young age, Tadahiro Amatsu stands out with his heterochromatic eyes—brown and light hazel. However, his left eye hides a mysterious secret, attracting the attention of the masked sorcerer Ayatara Miramune and his demon followers. In order to battle the spreading demonic threat, Yuzu Hieda, an aspiring priestess, enlists the help of four fellow high school girls. Guided by Yuzu's older sister Kurako, the five budding priestesses embark on rigorous training to hone their powers.