After claiming the featherweight championship title in Japan, Ippo Makunouchi basks in the support of his friends and coach, especially from his crush Kumi Mashiba. As he enjoys his newfound success, a formidable challenger emerges in the form of Kazuki Sanada, a doctor who fights with a strategic edge by leveraging his medical expertise. Beyond Sanada's physical prowess, his backing from the hospital's nurses adds to the tension for Ippo. Now, as the reigning champion, Ippo faces the daunting task of defending his title, overcoming this skilled opponent, and winning the heart of the woman he adores.