In the midst of the mid-1800s, a tale unfolds featuring a young Western-trained doctor named Ryo-an and a striving samurai upholding ancient traditions. Inspired by Tezuka's great grandfather, Ryo-an, and set in Edo's Koishigawa during the Second Year of Ansei, 1855, the narrative revolves around Manjiro Ibutani, a skilled yet humble swordsman of low samurai rank with a strong moral compass, and Ryoan Tezuka, a spirited individual torn between his amorous pursuits and his fervent dream of practicing medicine. As the turbulent end of the Tokugawa Period (1600-1868 CE) looms large, these contrasting personalities navigate the trials of youth, shaping their destinies amidst a changing cultural landscape.